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This question already has an answer here:

Can anyone suggest a program that can tell me which process is using which files? I need a GUI program that I can run on Windows Server 2008.

marked as duplicate by Der Hochstapler Oct 23 '14 at 15:42

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migrated from stackoverflow.com Sep 5 '10 at 11:01

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"Ever wondered which program has a particular file or directory open? Now you can find out. Process Explorer shows you information about which handles and DLLs processes have opened or loaded."

http://technet.microsoft.com/en-us/sysinternals/bb896653.aspx