I have a Mac (specifically Snow Leopard), so I'm used to Cmd+* to do things. My mail, for bold, underline, and italics, uses Ctrl+b/u/i instead of Cmd+b/u/i. How can I remap these three key combinations for one application only, or do something similar?
I don't know about Prism or web applications, but for normal OS X applications there's the Keyboard Shortcuts preferences:
You can also modify the property list that stores the shortcuts directly with something like:
defaults write com.apple.mail NSUserKeyEquivalents -dict-add "New Message" "@Y"