With Microsoft Office 2013 and 2016, Microsoft Office Upload Center runs automatically and shows up in the system tray. I don't use it and want stop it from running.
How can I remove that program completely?
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"You can't disable it and if you remove it from start up it still loads up anyway. All you can do is open task manager and end the process for MSOSYNC.EXE, pretty lame I know, but there's no way of disabling it and this info is coming from the office365 forum!"
You can disable the Microsoft Office Upload Center easily in the registry- but this is the only way.
Microsoft went out of their way to stop people from doing this in the GUI, and even MSCONFIG won't work.
Here's the registry fix (only tested on Windows 7 + Office 2010... see other answers for more recent versions of Windows/Office):
and delete the OfficeSyncProcess entry that points to the current location of MSOSYNC.EXE.
Microsoft's arrogance on this whole issue is astonishing:
Many people are turning to forums in frustration to turn off this feature.
It shouldn't be enabled automatically when you simply run SharePoint/SkyDrive once- and if it is, then it should be possible to turn it off without rolling up your sleeves and hacking the registry.
Poor show, Microsoft. Poor show.
To disable/configure this open up the
Task Scheduler and click on the
Task Scheduler Library node.
You should see a task here labelled
Microsoft Office 15 Sync Maintenance for USERNAME.
Disable the whole trigger (right click and choose
disable) or change the Properties of this to amend the trigger that starts the job. For instance, you can delete the trigger that starts on user log on.
Using Microsoft Office 2016 with Windows 10 and the now completely integrated OneDrive application...
Updated for OneDrive Version 2016 (Build 17.3.6517.0809) as of Aug. 2016
Right click on the OneDrive tray icon and choose settings.
Navigate to the Office tab and uncheck "Use Office to sync office files"
Note, this answer was written in the early days of Office 2013 and is reported to be out of date. Original answer follows...
Out of desperation I renamed the executable msosync.exe so that office cannot find it. Dirty, yes, but I have had no problems with this approach and now my computer works much better again :)
This is a terrible MS pushed annoyance, and to make it worse, MS insists that you use it by constantly avoiding previous removal procedures. So here is my attempt to collect and update some (currently) working solutions. The post answers here will probably need to be updated again, in a few months...
These instructions are for disabling
Microsoft Office Upload Center
on the MS Office 2013 Home & Student Edition on Windows 8.1.
Kill the processes:
a) Stop the system service "Microsoft Office Service". (Perhaps permanently disable?)
Process Explorer to kill all of the following processes if present:
integratedoffice.exe MSOSYNC.EXE CSISYNCCLIENT.EXE OSPPSVC.EXE MSOUC.EXE
c) Rename the following
*.EXE files by adding ".disabled" to thier filenames in :
C:\Program Files\Microsoft Office 15\root\office15\MSOUC.EXE C:\Program Files\Microsoft Office 15\root\office15\MSOSYNC.EXE
and possibly also:
C:\Program Files\Microsoft Office 15\root\office15\MSOHTMED.EXE
 This folder have also been found to be located in:
C:\Program Files\Microsoft Office\Office15\
Replace the above files with fake
a) Create and edit a new text file called MSOSYNC.txt with command:
b) Copy and rename the file MSOSYNC.txt to:
c) Set correct file permissions, if necessary.
Remove the entry from the Task Scheduler:
a) Open Control Panel and go to:
Control Panel >> System and Security >> Administrative Tools
b) Select and open "Task Scheduler".
c) Click on the "Task Scheduler Library" icon. [on the left side/pane]
d) Find and click on:
"Microsoft Office 15 Sync Maintenance for - "
e) Click on the "Actions" [tab] and check that it reads something like:
C:\Program Files\Microsoft Office 15\Root\Office15\MsoSync.exe
f) In the right pane, under "Selected Item", click "Disable"
Other suspicious tasks to check:
1) Expand the "Task Scheduler Library" tab [on the left pane] 2) >> Microsoft >> Office >> Office Automatic Updates 3) >> Microsoft >> Windows >> SettingSync >> BackgroundUploadTask 4) >> Microsoft >> Windows >> SkyDrive >> Idle Sync Maintenance Task
Disallow Office to connect to the internet.
a) Open any office application like Word, and go to:
File >> Options >> Trust Center [on bottom left]
b) Under "Microdsoft Word Trust Center" header [bottom], select:
"Trust Center Settings..." button [bottom right]
c) In the new "Trust Center" window go to:
Privacy Options [on bottom left]
d) Under "Privacy Options" header, unselect
Allow Office to connect to the Internet.
Here are some additional possible solutions, but which I have not tried:
MSOSYNC.EXEto 'List of disallowed applications'.
You might want to have a look at this MS answer.
In that case the user removed Office 2013, but still had SkyDrive Desktop app installed, and there was a SkyDrive setting referring to the upload center.
In my case, I only had Sharepoint Designer 2013 installed (Office suite was stuck at 2010, and I already disabled its upload center): that answer worked for me.