Not really. There are many things that can cause a false positive as well as false negatives.
Off the top of my head examples include:
- Mail server temporarily down
- Incorrectly configured spamfilter being way too aggressive
- Server running properly, but mailbox isn't receiving it (Happened on my server because of a config-screwup)
The only true indication that an address is working as intended is getting a reply from it. And even that might be temporarily. On the flipside, any issue reported when you try to reach it can also be temporary.
The only exception that I can think of is if the domain simply doesn't exist.