I use Firefox 3.5.7. I am also using the Firebug extension for developing.
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about:config in the address bar and filter to
network.http.use-cache. Set it to
false to stop Firefox from using cached files.
You can do the same with the Web Developer Toolbar:
nsIDOMOfflineResourceList. You can get information on the MDC specific page.
Or the simple solution could be just to use
Ctrl+F5 to reload the page and force the refresh. If it's for websites you develop, you can add a variable at the end of your filename (for example a timestamp or a random number), something like
src="../myFile.js?random=1551533331", so the browser will think the file is different and refresh your file everytime (I have never tried it, but it should do the job).