There is a point when enough is enough. And it is now. Ads, vids, pop up, hover, cover, whizz-bang doodle bling and autoplay … I can't stand it any more. With HTML5, this ad crap has become a plight on the Internet, and decisive counter-measures have to be taken.
I'm using IE11 on Windows 7 and 8.1 (no Edge/10 for me, no Firefox, no Chrome, no thanks). You can neutralize Flash by uninstalling or via menu » Security » ActiveX filtering. But there is no way to disable iframes of html5 video in IE11, which are major sources of annoyance.
To find out what sites you need to allow, use the network tab on the F12 tool.